Structure of PDB 4wy0 Chain E

Receptor sequence
>4wy0E (length=247) Species: 235909 (Geobacillus kaustophilus HTA426) [Search protein sequence]
EMQKGGVIMDVVNAEQAKIAEAAGAVAVMALEGGVARMADPTVIEEVMNA
VSIPVMAKVRIGHYVEARVLEALGVDYIDESEVLTPADEEFHIDKRQFTV
PFVCGCRDLGEAARRIAEGASMLRTKGEPGTGNIVEAVRHMRKVNAQIRK
VVNMSEDELVAEAKQLGAPVEVLREIKRLGRLPVVNFAAGGVTTPADAAL
MMHLGADGVFVGSGIFKSENPEKYARAIVEATTHYEDYELIAHLSKG
3D structure
PDB4wy0 Crystal structures capture three states in the catalytic cycle of a pyridoxal phosphate (PLP) synthase.
ChainE
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.3.3.6: pyridoxal 5'-phosphate synthase (glutamine hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R5P E H115 R137 R138 H92 R114 R115
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0016843 amine-lyase activity
GO:0036381 pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0008615 pyridoxine biosynthetic process
GO:0042819 vitamin B6 biosynthetic process
GO:0042823 pyridoxal phosphate biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4wy0, PDBe:4wy0, PDBj:4wy0
PDBsum4wy0
PubMed25568319
UniProtQ5L3Y2|PDXS_GEOKA Pyridoxal 5'-phosphate synthase subunit PdxS (Gene Name=pdxS)

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