Structure of PDB 4v8l Chain E

Receptor sequence
>4v8lE (length=2822) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
AHALVDRLSAGEPYAVAFGGQGSAWLETLEELVSSAGIESELATLAGEAE
LLLEPVASELVVVRPIGFEPLQWVRALAAEEPVPSDKQLTSAAVSVPGVL
LTQIAAVRALARQGMDLTATPPVAVAGHSQGVLAVQALAAKGAKDVELLA
LAQLIGAAGTLVARRRGITVLGDRPPMVSVTNADPERIYELLEEFSSDVR
TVLPPVLSIRNGRRSVVITGTPEQLSRFELYCTQIAEKEEAERKNKLRGG
AVFAPVFDPVQVEVGFHTPRLSDGIEIVGRWAETVGLDVELAKELTESIL
VRQVDWVDEITELHEAGARWILDLGPGDILTRLTAPVIRGLGIGIVPAAT
RGGQRNLFTVGAVPEVARPWSSYAPTVVKLPDGSVKLETKFTRLTGRSPI
LLAGMTPTTVDAKIVAAAANAGHWAELAGGGQVTEQIFNDRIAELETLLE
PGRAIQFNTLFLDPYLWKLQVGGKRLVQRARQSGAPIDGLVVSAGIPDLE
EAVDIIDELNEVGISHVVFKPGTVEQIRSVIRIAAEVPTKPVIVHIEGGR
AGGHHSWEDLDDLLLATYSELRSRSNITICVGGGIGTPERSAEYLSGRWA
EVHGYPLMPIDGILVGTAAMATLEATTSPQVKQLLVETKGTEAWVGAGKA
ANGMASGRSQLGADIHEIDNAASRCGRLLDEVAGDADAVAERRDEIIAAM
AQTAKPYFGDVAEMTYLQWLRRYVELAIGDGNSTADTKRPDSPWLDITWR
DRFEQMLKRAEARLHPQDFGPIETLFDADADGERLLEDPEAAITALLQRY
PDAETVVLHPADVPFFVELCKTLGKPVNFVPVIDKDVRRWWRSDSLWQAH
DARYEADQVCVIPGTAAVAGITRVDEPVGELLDRFEQAAVDEVLGAGAPP
PPPPPPPPPPPPPPGPLAVVLDAPDVLWAGRMSVNPVHRIAAPPPPPPPP
PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPIEIRFTLTDVVRSGGA
PIVEVDDAATAMRAVLAIAAGVEGPENLPKVVDNTATVTVDWDPERVADH
TGVTATFGAPLAPTLTVVPDALVGRCWPAVFAAIGSAATEAGFPVIEGLL
SLVHLDHAARLLAELPKEPAEFTVTAKASAATDTEVGRVVPVSVEVRNAA
DGALLATLEERFAIRPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPVTV
GAPVDMRPFAVVSGDHNPIHTDRAAALLAGLEGPIVHGMWLSAAAQHVVT
ATDGKPVPPAKLIGWTARFLGMVKPGDQVDFRVDRVGIDVGAEVLEVSAR
IGSELVMAATARLAAPKTVYAFPGQGIQHKGMGMEVRARSKAARKVWDSA
DKFTRETLGFSVLHVVRDNPTSLIASGVHYHHPDGVLFLTQFTQVAMATV
AAAQVAEMREQGAFVEGAIACGHSVGEYTALACVSGVYELEALLEVVFHR
GSKMHDIVPRDELGRSNYRLAAIRPSQIDLDDADVKDFVAEISERTGEFL
EIVNFNLRGSQYAIAGTVAGLEALEEEIERRRQITGGKRSFILVPGIDVP
FHSSVLRVGVADFRRSLERVMPRDKDPELIIGRYIPNLVPRPFTLDRDFI
QEIRDLVPAEPLDEVLADYDTWRNEKPKELCRKVVIELLAWQFASPVRWI
ETQDLLFIEEAAGGLGVERFVEIGVKSAPTVAGLATNTLKLPEYSHSTVE
VLNSERDAAVLFATDSAALGEFAEKVTGPDGVLASAARLVLNQLGLSDVV
TTPEAATDAELIDLVTAELGSDWPRLVAPTFDARKAVVFDDRWASAREDL
VKLWLAEEPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP
PPPPPPPPPPPPPPPPPPDEVAVVTGASKGSIAASVVGQLLDGGATVIAT
TSRLDDDRLAFYKQLYRDHARFDATLWVVPANMASYSDIDKLVEWVGTEQ
TESLGPQSIHLKDAQTPTLLFPFAAPRVAGDMSEVGSRAEMEMKVLLWAV
QRLISGLSKIGAERDIASRLHVVLPGSPNRGMFGGDGAYGEAKSALDALE
NRWSAEKSWAERVSLAHALIGWTKGTGLMGQNDAIVSAVEEAGVTTYTTD
EMAAMLLDLCTVETKVAAAGAPVKVDLTGGLGDIKIDMAELAAKAREEMS
GAADPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPDVDPADLVVIVGGA
ELGPYGSSRTRFEMEVSGELSAAGVLELAWTTGMVKWEDDPKAGWYDTET
GELVPECEIVERYHDAVVERCGIREFVDDGAIDPDHASPLLVSVFLDKDF
TFVVSSEADARAFVQFDPEHTVARPLPDSSDWEVTRKAGTEIRVPRKTKL
SRTVGAQIPTGFDPTVWGISPDMASSIDRVALWNIVATVDAFLSSGFTPT
ELMRWVHPSQVASTQGTGMGGMTSMQTMYHGNLLGRAKPNDILQEVLPNV
VAAHVMQSYVGGYGAMVHPVGACATAAVSVEEGVDKIKLGKADLVIAGGF
DDLTLEAIIGFGDMAATADTEMMRAKGISDSKFSRANDRRRLGFLEAQGG
GTILLARGDLALKMGLPVLAVVGYAQSFADGVHTSIPAPGLGALGAARGG
RESTLARSLAQLGVGADDIAVISKHDTSTLANDPNETELHERIADSMGRA
PGNPLFIVSQKTLTGHAKGGAAVFQMMGLCQILRDGVIPPNRSLDCVDDE
LATSGHFVWVREPLDLRGKFPLKAGLVTSLGFGHVSGLVALVHPEAFIAA
LDPSEREDYRTRAEQRMLAGQRRLVSAIAGGRPMYEKPADRRFDHDVPEK
RQEAAMLLSTDARLGENDQYVL
3D structure
PDB4v8l 7.5-A Cryo-Em Structure of the Mycobacterial Fatty Acid Synthase.
ChainE
Resolution7.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C2740 H2892 E2903 K2928 H2933 L2997 F2999
Catalytic site (residue number reindexed from 1) C2473 H2625 E2636 K2661 H2666 L2730 F2732
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN E G434 M435 T436 P437 L490 S523 K550 E577 A581 G613 G614 G646 T647 I892 G404 M405 T406 P407 L460 S493 K520 E547 A551 G583 G584 G616 T617 I862
Gene Ontology
Molecular Function
GO:0004312 fatty acid synthase activity
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
Cellular Component
GO:0005835 fatty acid synthase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4v8l, PDBe:4v8l, PDBj:4v8l
PDBsum4v8l
PubMed23291528
UniProtA0R1H7

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