Structure of PDB 4uyg Chain E

Receptor sequence
>4uygE (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]
SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDL
STVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVF
EFRYAKMPD
3D structure
PDB4uyg The Discovery of I-Bet726 (Gsk1324726A), a Potent Tetrahydroquinoline Apoa1 Up-Regulator and Selective Bet Bromodomain Inhibitor.
ChainE
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 73B E W370 P371 L381 N429 H433 V435 W24 P25 L35 N83 H87 V89 MOAD: Kd=4.4nM
BindingDB: IC50=158nM,Kd=25nM
External links
PDB RCSB:4uyg, PDBe:4uyg, PDBj:4uyg
PDBsum4uyg
PubMed25249180
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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