Structure of PDB 4uw1 Chain E

Receptor sequence
>4uw1E (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVV
NKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYI
GGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRV
TLGKSFLQFSTIKMAHAPPGHHSVIGRPSLAYAEYVIYRGEQAYPEYLIT
YQIMKPE
3D structure
PDB4uw1 Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1-Ones as Potent and Selective Tankyrase Inhibitors
ChainE
Resolution3.37 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E C1234 H1237 C1242 C130 H133 C138
BS02 92R E H1184 G1185 S1186 H1201 Y1203 Y1213 A1215 K1220 S1221 Y1224 E1291 H80 G81 S82 H97 Y99 Y109 A111 K116 S117 Y120 E184
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4uw1, PDBe:4uw1, PDBj:4uw1
PDBsum4uw1
PubMed
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

[Back to BioLiP]