Structure of PDB 4tuh Chain E

Receptor sequence
>4tuhE (length=140) Species: 9606 (Homo sapiens) [Search protein sequence]
MSQSNRELVVDFLSYKLSQKGYSWSQMAAVKQALREAGDEFELRYRRAFS
DLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVD
KEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG
3D structure
PDB4tuh Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.
ChainE
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 38H E A93 E96 F97 Y101 R102 F105 S106 L108 T109 L130 G138 R139 A142 S145 F146 A149 L194 Y195 A37 E40 F41 Y45 R46 F49 S50 L52 T53 L74 G82 R83 A86 S89 F90 A93 L138 Y139 BindingDB: Ki=0.380000nM,EC50=60nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4tuh, PDBe:4tuh, PDBj:4tuh
PDBsum4tuh
PubMed24944740
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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