Structure of PDB 4s0h Chain E

Receptor sequence
>4s0hE (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
GIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYIL
LMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQL
VSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADTAFCTHVFPETAF
IAVTSYQNHKITQLKIENNPFAKGFRG
3D structure
PDB4s0h Intermolecular Interactions of Cardiac Transcription Factors NKX2.5 and TBX5.
ChainE
Resolution2.817 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E N162 S175 T215 P231 K234 G235 N110 S123 T154 P170 K173 G174
BS02 dna E R81 R82 K159 Y217 T223 N230 F232 F236 R29 R30 K107 Y156 T162 N169 F171 F175
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:4s0h, PDBe:4s0h, PDBj:4s0h
PDBsum4s0h
PubMed26926761
UniProtQ99593|TBX5_HUMAN T-box transcription factor TBX5 (Gene Name=TBX5)

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