Structure of PDB 4ple Chain E

Receptor sequence
>4pleE (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
AAASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMC
KMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVV
HGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQR
EFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKF
GQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLH
3D structure
PDB4ple Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.
ChainE
Resolution1.752 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E F354 N529 E534 F58 N233 E238
BS02 peptide E F354 R361 V371 M375 L531 F58 R65 V75 M79 L235
BS03 EPH E T341 F342 M345 W382 I387 H390 I416 G421 L424 M428 A513 E514 Y516 K520 T45 F46 M49 W86 I91 H94 I120 G125 L128 M132 A217 E218 Y220 K224
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity

View graph for
Molecular Function
External links
PDB RCSB:4ple, PDBe:4ple, PDBj:4ple
PDBsum4ple
PubMed26553876
UniProtO00482|NR5A2_HUMAN Nuclear receptor subfamily 5 group A member 2 (Gene Name=NR5A2)

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