Structure of PDB 4p6x Chain E

Receptor sequence
>4p6xE (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
ATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVI
AAVKWAKAIPGFRNLHLDDQMTLLQYSWMALMAFALGWRSYRQSSANLLY
FAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKVLLLL
STIPKDGLKSQALFDAIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLL
DSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKL
LFHQK
3D structure
PDB4p6x Structures and mechanism for the design of highly potent glucocorticoids.
ChainE
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E V575 K579 R585 L589 M593 E755 N759 V53 K57 R63 L67 M71 E233 N237
BS02 HCY E N564 G567 Q570 M604 F623 Q642 Y735 C736 T739 N42 G45 Q48 M82 F101 Q120 Y213 C214 T217 MOAD: Ki=91nM
BindingDB: Ki=30nM
External links
PDB RCSB:4p6x, PDBe:4p6x, PDBj:4p6x
PDBsum4p6x
PubMed24763108
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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