Structure of PDB 4p3w Chain E

Receptor sequence

>4p3wE (length=172) Species: 9606 (Homo sapiens) [Search protein sequence]

GSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAE
MGTHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVP
AEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYE
VSVKFNEEHIPDSPFVVPVASP

3D structure

PDB

4p3w Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin peptide

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	E	M2207 G2208 T2263 R2264 A2268 G2269 G2270 L2271 A2272 I2273 A2274 V2275 E2276 G2277 P2278 S2279 K2280 A2281 I2283 F2285 E2301	M51 G52 T107 R108 A112 G113 G114 L115 A116 I117 A118 V119 E120 G121 P122 S123 K124 A125 I127 F129 E145
BS02	peptide	E	G2223 P2225 F2226 Q2227 F2228 T2229 P2232 E2313 E2314 H2315 S2319	G67 P69 F70 Q71 F72 T73 P76 E157 E158 H159 S163

Gene Ontology

	Molecular Function
GO:0051015	actin filament binding

	Biological Process
GO:0030036	actin cytoskeleton organization

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4p3w, PDBe:4p3w, PDBj:4p3w
PDBsum	4p3w
PubMed
UniProt	P21333\|FLNA_HUMAN Filamin-A (Gene Name=FLNA)

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