Structure of PDB 4p0s Chain E

Receptor sequence
>4p0sE (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
QQQPLELRPGEYRVLLCVDIGETRGPELLRELQRLHVTHTVRKLHVGDFV
WVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRC
GLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESA
AYLALLTRGLQRLYQGHTLRSRPWGTPGPNPLCSLLTFSDFNAGAREVFA
RQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCG
RLQRNLGPALSRTLSQLYCSYGPLT
3D structure
PDB4p0s Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates.
ChainE
Resolution6.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E I344 R350 K353 N390 A535 I85 R91 K94 N131 A259
BS02 dna E R279 K302 H304 G484 S486 K489 R530 R24 K43 H45 G208 S210 K213 R254
BS03 dna E E351 Q352 R355 E92 Q93 R96
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0008821 crossover junction DNA endonuclease activity
Biological Process
GO:0006302 double-strand break repair
GO:0006308 DNA catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4p0s, PDBe:4p0s, PDBj:4p0s
PDBsum4p0s
PubMed24733841
UniProtQ96NY9|MUS81_HUMAN Crossover junction endonuclease MUS81 (Gene Name=MUS81)

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