Structure of PDB 4ol8 Chain E

Receptor sequence
>4ol8E (length=381) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
PVWLQQKYREIIRNDLPPRPVKHDIEIKPGARLPRLQPYHVTEKNEQEIN
KIVQKLLDNKFIVPSKSPCSSPVVLVPGTFRLCVDYRTLNKATISDPFPL
PRIDNLLSRIGNAQIFTTLDLHSGYHQIPMEPKDRYKTAFVTPSGKYEYT
VMPFGLVNAPSTFARYMADTFRDLRFVNVYLDDILIFSESPEEHWKHLDT
VLERLKNENLIVKKKKCKFASEETEFLGYSIGIQKIAPHKCAAIRDFPTP
KTVKQAQRFLGMINYYRRFIPNCSKIAQPITEKQDKAIDKLKSPVLVPFN
YRLTTDASKDGIGAVLEVGYFSKSLESAQGELELLGIIKALHHFRYMLHG
KHFTLRTNHIEPARRVQRWLDDLATYDFTLE
3D structure
PDB4ol8 Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry.
ChainE
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.26.4: ribonuclease H.
3.4.23.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna E C114 D116 R118 N121 L131 F185 G186 L187 V188 P191 N297 C83 D85 R87 N90 L100 F154 G155 L156 V157 P160 N264
BS02 dna E Y211 D213 L258 K287 Q290 R291 G294 Y298 Y180 D182 L227 K254 Q257 R258 G261 Y265
External links
PDB RCSB:4ol8, PDBe:4ol8, PDBj:4ol8
PDBsum4ol8
PubMed24608367
UniProtQ99315|YG31B_YEAST Transposon Ty3-G Gag-Pol polyprotein (Gene Name=TY3B-G)

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