Structure of PDB 4nru Chain E

Receptor sequence
>4nruE (length=477) Species: 223997 (Murine norovirus 1) [Search protein sequence]
RPSGTYAGLPIADYGDAPPLSTKTMFWRTSPEKLPPGAWEPAYLGSKDER
VDGPSLQQVMRDQLKPYSEPRGLLPPQEILDAVCDAIENRLENTLEPQKP
WTFKKACESLDKNTSSGYPYHKQKSKDWTGSAFIGDLGDQATHANNMYEM
GKSMRPIYTAALKDELVKPDKIYGKIKKRLLWGSDLGTMIRAARAFGPFC
DALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYTRWDSTQQRA
ILKRAGDIMVRLSPEPDLARVVMDDLLAPSLLDVGDYKIVVEEGLPSGCP
CTTQLNSLAHWILTLCAMVEVTRVDPDIVMQESEFSFYGDDEVVSTNLEL
DMVKYTMALRRYGLLPTRADKEEGPLERRQTLQGISFLRRAIVGDQFGWY
GRLDRASIDRQLLWTKGPNHQNPFETLPGHQRPSQLMALLGEAAMHGEKY
YRTVASRVSKEAVVPRHRSVLRWVRFG
3D structure
PDB4nru Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.
ChainE
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2NG E M219 R392 Q414 W417 T418 K419 R436 Q439 M216 R389 Q411 W414 T415 K416 R432 Q435 MOAD: ic50=115nM
BS02 2NG E P79 E81 R326 V327 D328 R364 P76 E78 R323 V324 D325 R361 MOAD: ic50=115nM
BS03 MG E D240 D344 E345 S389 D237 D341 E342 S386
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4nru, PDBe:4nru, PDBj:4nru
PDBsum4nru
PubMed24622391
UniProtQ80J95|POLG_MNV1 Genome polyprotein (Gene Name=ORF1)

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