Structure of PDB 4nb4 Chain E

Receptor sequence
>4nb4E (length=259) Species: 282458 (Staphylococcus aureus subsp. aureus MRSA252) [Search protein sequence]
MKVGIDAGGTLIKIVQEQDNQRTFKTELTKNIDQVVEWLNQQQIEKLCLT
GGNAGVIAENIIPAQIFVEFDAASQGLGILLKEQGHDLADYIFANVGTGT
SLHYFDGQSQRRVGGIGTGGGMIQGLGYLLSQITDYKQLTDMAQHGDRNT
IDLKVRHPPIPGDLTAANFGHVLHHLDADFTPSNKLAAVIGVVGEVVTTM
AITVAREFKTENIVYIGSSFHNNALLRKVVEDYTVLRGCKPYYVENGAFS
GAIGALYLE
3D structure
PDB4nb4 Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus.
ChainE
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E G8 G9 T10 L11 K13 G98 T99 G121 Q125 Y137 S225 S226 G8 G9 T10 L11 K13 G97 T98 G120 Q124 Y136 S218 S219
BS02 SH3 E E70 G100 T101 S102 R113 G116 E69 G99 T100 S101 R112 G115
BS03 SH3 E T172 A173 E202 Y240 T165 A166 E195 Y233
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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External links
PDB RCSB:4nb4, PDBe:4nb4, PDBj:4nb4
PDBsum4nb4
PubMed24470271
UniProtQ6G7I0|COAW_STAAS Type II pantothenate kinase (Gene Name=coaW)

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