Structure of PDB 4nah Chain E

Receptor sequence
>4nahE (length=160) Species: 196620 (Staphylococcus aureus subsp. aureus MW2) [Search protein sequence]
MEHTIAVIPGSFDPITYGHLDIIERSTDRFDEIHVCVLKNSKKEGTFSLE
ERMDLIEQSVKHLPNVKVHQFSGLLVDYCEQVGAKTIIRGLRAVSDFEYE
LRLTSMNKKLNNEIETLYMMSSTNYSFISSSIVKEVAAYRADISEFVPPY
VEKALKKKFK
3D structure
PDB4nah Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.
ChainE
Resolution2.38 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H19 K43 R92 S130
Catalytic site (residue number reindexed from 1) H19 K43 R92 S130
Enzyme Commision number 2.7.7.3: pantetheine-phosphate adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS E S11 G18 H19 R89 G90 R92 S121 Y125 I128 S130 S131 S11 G18 H19 R89 G90 R92 S121 Y125 I128 S130 S131
BS02 2VJ E P9 C36 V37 G73 L75 Y99 L103 N107 P9 C36 V37 G73 L75 Y99 L103 N107
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004595 pantetheine-phosphate adenylyltransferase activity
GO:0005524 ATP binding
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0009058 biosynthetic process
GO:0015937 coenzyme A biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:4nah, PDBe:4nah, PDBj:4nah
PDBsum4nah
PubMed24041904
UniProtP63820|COAD_STAAW Phosphopantetheine adenylyltransferase (Gene Name=coaD)

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