Structure of PDB 4n0o Chain E

Receptor sequence
>4n0oE (length=396) Species: 299386 (Equine arteritis virus Bucyrus) [Search protein sequence]
AVCTVCGAAPVAKSACGGWFCGNCVPYHAGHCHTTSLFACGHDIMYRSTY
CTMCEGSPKQMVPKVPHPILDHLLCHIDYGSKEELTLVVADGTTSPPGRY
KVGHKVVAVVADVGGNIVFGCPGSHIVPLQDTLKGVVVNKALKNAAASEY
VEGPPGSGKTFHLVKDVLAVVGSATLVVPTHASMLDCINKLKQAGADPYF
VVPKYTVLDFPRPGSGNITVRLPQVGTSEGETFVDEVAYFSPVDLARILT
QGRVKGYGDLNQLGCVGPASVPRNLWLRHFVSLEPLRVCHRFGAAVCDLI
KGIYPYYEPAPHTTKVVFVPNPDFEKGVVITAYHKDRGLGHRTIDSIQGC
TFPVVTLRLPTPQSLTRPRAVVAVTRASQELYIYDPFDQLSGLLKF
3D structure
PDB4n0o Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase.
ChainE
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.21.-
3.4.22.-
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E Y81 G101 R102 T185 H186 Q229 V230 V271 Y338 H339 D350 R374 Y79 G98 R99 T180 H181 Q224 V225 V266 Y333 H334 D345 R369
BS02 ZN E H29 H32 C33 H28 H31 C32
BS03 ZN E C42 H44 C53 C40 H42 C51
BS04 ZN E C22 C25 C21 C24
BS05 CA E A2 V3 A1 V2
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:4n0o, PDBe:4n0o, PDBj:4n0o
PDBsum4n0o
PubMed24369429
UniProtP19811|RPOA_EAVBU Replicase polyprotein 1ab (Gene Name=rep)

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