Structure of PDB 4mgi Chain E

Receptor sequence
>4mgiE (length=627) Species: 10090 (Mus musculus) [Search protein sequence]
MRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESH
AKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALV
NDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVL
EKVQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMP
NTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLL
QEDDVAMAFLEEFYVSVSDDARMMAAFKEQLPELEKIVRQPIRGSDEVLF
KVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVV
LKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMS
SKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNE
IQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSN
VAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIP
FMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNHQ
DVRSYVRQLNVIDNQRTLSQMSHRLEP
3D structure
PDB4mgi Selective activation of Epac1 and Epac2
ChainE
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP E F367 V386 C395 F403 G404 A407 R414 A415 L449 K450 K489 F58 V77 C86 F94 G95 A98 R105 A106 L140 K141 K165
BS02 CMP E V365 V387 G392 S417 V419 S541 Q542 V56 V78 G83 S108 V110 S217 Q218
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4mgi, PDBe:4mgi, PDBj:4mgi
PDBsum4mgi
PubMed
UniProtQ9EQZ6|RPGF4_MOUSE Rap guanine nucleotide exchange factor 4 (Gene Name=Rapgef4)

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