Structure of PDB 4l5c Chain E

Receptor sequence
>4l5cE (length=289) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
KVKVGIIGGSGFDDPNLFKKVGVRQVTTPFGKPSDTLVEGFVGDVACVVL
PRHGKGHLIPPSEVNYRANVWALKDLGCTHILATACGSLQEDLVPGDFVV
LNQFMDKTWGRENTFYGSKPDSLKGVLHMPMAEPFCERTRQILIQAARNK
SINVYDKKTMDKSACIHPCVHAEGSAVTINGPRFSTRCESFIHKAMGLDI
VNMTLVPEVSLAREAGLSYASIAIVTDFDCWKSEEEHVCVDMVLEQFRKS
VVHVREILLEAVALIGAEDWTKTIEANKALVMSSRQDLL
3D structure
PDB4l5c Crystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5'-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage Pathway.
ChainE
Resolution2.075 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K34 H59 D230 D232
Catalytic site (residue number reindexed from 1) K32 H57 D227 D229
Enzyme Commision number 2.4.2.28: S-methyl-5'-thioadenosine phosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADE E A88 C89 G90 F187 N205 M206 T229 D230 A85 C86 G87 F184 N202 M203 T226 D227
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0017061 S-methyl-5-thioadenosine phosphorylase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0009116 nucleoside metabolic process
GO:0019509 L-methionine salvage from methylthioadenosine
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4l5c, PDBe:4l5c, PDBj:4l5c
PDBsum4l5c
PubMed27935959
UniProtI0B503

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