Structure of PDB 4k8n Chain E

Receptor sequence
>4k8nE (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]
FNLKVVLVSFKQCLDEKEEVLLDPYIASWKGLVRFLNSLGTIFSFISKDV
VSKLRIMERLRGGPQSEHYRSLQAMVAHELSNRLVDLERRSHHPESGCRT
VLRLHRALHWLQLFLEGLRTSPEDARTSALCADSYNASLAAYHPWVVRRA
VTVAFCTLPTREVFLEAMNVGPPEQAVQMLGEALPFIQRVYNVSQKLYAE
HSLLDLP
3D structure
PDB4k8n Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids.
ChainE
Resolution3.102 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1Q0 E P151 W152 V153 P144 W145 V146
BS02 1Q0 E W36 I53 D56 V57 K60 R106 W117 H150 W29 I46 D49 V50 K53 R99 W110 H143
Gene Ontology
Molecular Function
GO:0005543 phospholipid binding
GO:0008289 lipid binding
GO:0120013 lipid transfer activity
GO:1902387 ceramide 1-phosphate binding
GO:1902388 ceramide 1-phosphate transfer activity
Biological Process
GO:0006869 lipid transport
GO:0010507 negative regulation of autophagy
GO:0032691 negative regulation of interleukin-1 beta production
GO:0035627 ceramide transport
GO:0046836 glycolipid transport
GO:0120009 intermembrane lipid transfer
GO:1900226 negative regulation of NLRP3 inflammasome complex assembly
GO:1902389 ceramide 1-phosphate transport
Cellular Component
GO:0005634 nucleus
GO:0005640 nuclear outer membrane
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4k8n, PDBe:4k8n, PDBj:4k8n
PDBsum4k8n
PubMed23863933
UniProtQ5TA50|CPTP_HUMAN Ceramide-1-phosphate transfer protein (Gene Name=CPTP)

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