Structure of PDB 4ign Chain E

Receptor sequence

>4ignE (length=332) Species: 9606 (Homo sapiens)

MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFAVVR
ENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDL
ASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEW
DLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETT
IAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQD
NPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELE
PGKLIESMEEFDEETKNKLKAGNALAFLGLER

3D structure

• PDB: 4ign Human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD): A structural and mechanistic unveiling.
• Chain: E
• Resolution: 2.329 Å

Enzymatic activity

• Enzyme Commision number: 4.1.1.45: aminocarboxymuconate-semialdehyde decarboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	E	H6 H8 H174 D291	H6 H8 H174 D291

Gene Ontology

Molecular Function

• GO:0001760 aminocarboxymuconate-semialdehyde decarboxylase activity
• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0016787 hydrolase activity
• GO:0016831 carboxy-lyase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006569 tryptophan catabolic process
• GO:0019748 secondary metabolic process
• GO:1904985 negative regulation of quinolinate biosynthetic process
• GO:1905004 picolinic acid biosynthetic process
• GO:1905012 regulation of 'de novo' NAD biosynthetic process from tryptophan

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4ign, PDBe:4ign, PDBj:4ign
• PDBsum: 4ign
• PubMed: 25392945
• UniProt: Q8TDX5|ACMSD_HUMAN 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (Gene Name=ACMSD)