Structure of PDB 4gbe Chain E

Receptor sequence
>4gbeE (length=244) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYIL
ADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQ
DPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFA
EKAQNAFFYCESYADSMARADDASVVYCDPPYAPLSFTLEQQAHLAEIAE
GLVERHIPVLISNHDTMLTREWYQRAKLHVVKVKVDELLALYKP
3D structure
PDB4gbe Structural Basis of Selective N-6 adenine methyltransferase Inhibition by Transition State Mimics
ChainE
Resolution2.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH E W10 F35 V36 A38 S40 D54 I55 Y165 D181 W8 F33 V34 A36 S38 D52 I53 Y163 D179
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
GO:0043565 sequence-specific DNA binding
GO:1904047 S-adenosyl-L-methionine binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006298 mismatch repair
GO:0009307 DNA restriction-modification system
GO:0009411 response to UV
GO:0032259 methylation
GO:1902328 bacterial-type DNA replication initiation

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Molecular Function
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Biological Process
External links
PDB RCSB:4gbe, PDBe:4gbe, PDBj:4gbe
PDBsum4gbe
PubMed
UniProtP0AEE8|DMA_ECOLI DNA adenine methylase (Gene Name=dam)

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