Structure of PDB 4f7w Chain E

Receptor sequence
>4f7wE (length=304) Species: 507522 (Klebsiella pneumoniae 342) [Search protein sequence]
LMTPYLQFNRHQWAALRTLTEDEITRLKGINEDLSLEEVAEIYLPLSRLL
NFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARVLQALL
SRWPEHRHVELITTDGFLHPNSVLKERGLMKKKGFPQSYDMHRLVKFVSD
LKSGVPQATAPVYSHLIYDVIPDGDKTVAQPDILILEGLNVLQSGMDYPH
DPHHVFVSDFVDFSIYVDAPEELLKSWYINRFLKFREGAFTDPDSYFHNY
AKLSKEEAVDIATSLWNEINLMNLKENILPTRERASLIMTKSANHSVNQV
RLRK
3D structure
PDB4f7w Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N-substituted pantothenamides.
ChainE
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E N1043 D1045 A1098 G1100 K1101 S1102 T1103 R1243 H1307 N31 D33 A86 G88 K89 S90 T91 R231 H295
BS02 PN4 E D1127 K1145 G1146 Y1180 Y1240 F1259 I1281 N1282 D115 K133 G134 Y168 Y228 F247 I269 N270
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4f7w, PDBe:4f7w, PDBj:4f7w
PDBsum4f7w
PubMed23553820
UniProtB5XYG3|COAA_KLEP3 Pantothenate kinase (Gene Name=coaA)

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