Structure of PDB 4e4l Chain E

Receptor sequence
>4e4lE (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
EVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPN
HIADLKKEIEILRNLYHENIVKYKGICTGIKLIMEFLPSGSLKEYLPKNK
NKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDF
GLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLH
ELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPD
EVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
3D structure
PDB4e4l Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors.
ChainE
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N1008 D1021
Catalytic site (residue number reindexed from 1) N136 D149
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0NH E L881 G882 E883 V889 A906 M956 F958 L959 R1007 N1008 L1010 D1021 L18 G19 E20 V26 A43 M84 F86 L87 R135 N136 L138 D149 BindingDB: EC50=210nM,Ki=1.7nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4e4l, PDBe:4e4l, PDBj:4e4l
PDBsum4e4l
PubMed22591402
UniProtP23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 (Gene Name=JAK1)

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