Structure of PDB 4doq Chain E

Receptor sequence
>4doqE (length=220) Species: 9823 (Sus scrofa) [Search protein sequence]
IVGGYTCAANSIPYQVSLNSGSHFCGGSLINSQWVVSAAHCYKSRIQVRL
GEHNIDVLEGNEQFINAAKIITHPNFNGNTLDNDIMLIKLSSPATLNSRV
ATVSLPRSCAAAGTECLISGWGNTKSSYPSLLQCLKAPVLSDSSCKSSYP
GQITGNMICVGFLEGGKDSCQGDSGGPVVCNGQLQGIVSWGYGCAQKNKP
GVYTKVCNYVNWIQQTIAAN
3D structure
PDB4doq Structure basis 1/2SLPI and porcine pancreas trypsin interaction
ChainE
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D101 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H40 D84 Q171 G172 D173 S174 G175
Enzyme Commision number 3.4.21.4: trypsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA E E69 N71 V74 E76 E79 E52 N54 V57 E59 E62
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0007586 digestion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Biological Process
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Cellular Component
External links
PDB RCSB:4doq, PDBe:4doq, PDBj:4doq
PDBsum4doq
PubMed24121345
UniProtP00761|TRYP_PIG Trypsin

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