Structure of PDB 4d0z Chain E

Receptor sequence

>4d0zE (length=495) Species: 9606 (Homo sapiens) [Search protein sequence]

KVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHD
QCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILV
DDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLD
SHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGF
DWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKY
DMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSG
TVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCK
PFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECH
NAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCREDDSRQKWEQ
IEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFTLNL

3D structure

PDB

4d0z Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N- Acetylgalactosaminyltransferase 2.

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	E	F463 A464	F389 A390
BS02	peptide	E	A266 F280 W282 W331 F361 H365 A464	A192 F206 W208 W257 F287 H291 A390
BS03	BBK	E	D458 L460 Y471 H474 N479	D384 L386 Y397 H400 N405
BS04	HWU	E	T143 D176 R201 D224 S225 H226 A307 G308 G309 V330 W331 G332 E334 H359 R362 Y367	T69 D102 R127 D150 S151 H152 A233 G234 G235 V256 W257 G258 E260 H285 R288 Y293
BS05	MN	E	D224 H226 H359	D150 H152 H285

Gene Ontology

	Molecular Function
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity
GO:0005515	protein binding
GO:0016757	glycosyltransferase activity
GO:0030145	manganese ion binding
GO:0030246	carbohydrate binding
GO:0046872	metal ion binding

	Biological Process
GO:0006486	protein glycosylation
GO:0006493	protein O-linked glycosylation
GO:0016266	O-glycan processing
GO:0018242	protein O-linked glycosylation via serine
GO:0018243	protein O-linked glycosylation via threonine
GO:0051604	protein maturation

	Cellular Component
GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005795	Golgi stack
GO:0016020	membrane
GO:0032580	Golgi cisterna membrane
GO:0048471	perinuclear region of cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4d0z, PDBe:4d0z, PDBj:4d0z
PDBsum	4d0z
PubMed	24954443
UniProt	Q10471\|GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (Gene Name=GALNT2)

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