Structure of PDB 4d0l Chain E

Receptor sequence
>4d0lE (length=479) Species: 9606 (Homo sapiens) [Search protein sequence]
SWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLP
QLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSRGTKLR
KLILSDRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLP
ARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSV
PARIPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLR
QELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIH
QVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVK
DRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGG
LDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIR
NLKERFHMSMTEEQLQLLVEQMVDGSMRS
3D structure
PDB4d0l Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors.
ChainE
Resolution2.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.67: 1-phosphatidylinositol 4-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 093 E P381 I547 Y583 I595 P597 V598 I673 D674 P182 I242 Y278 I290 P292 V293 I368 D369 BindingDB: IC50=19nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4d0l, PDBe:4d0l, PDBj:4d0l
PDBsum4d0l
PubMed24876499
UniProtQ9UBF8|PI4KB_HUMAN Phosphatidylinositol 4-kinase beta (Gene Name=PI4KB)

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