Structure of PDB 4cn7 Chain E

Receptor sequence
>4cn7E (length=77) Species: 9606 (Homo sapiens) [Search protein sequence]
TKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQE
3D structure
PDB4cn7 Structural Basis of Natural Promoter Recognition by the Retinoid X Nuclear Receptor.
ChainE
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E G144 K145 H146 Y147 K156 R164 V205 Q206 G14 K15 H16 Y17 K26 R34 V75 Q76 PDBbind-CN: Kd=155nM
BS02 dna E E153 G154 R161 R184 N185 Q188 R191 E23 G24 R31 R54 N55 Q58 R61 PDBbind-CN: Kd=155nM
BS03 ZN E C135 C138 C155 C5 C8 C25
BS04 ZN E C171 C177 C187 C190 C41 C47 C57 C60
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4cn7, PDBe:4cn7, PDBj:4cn7
PDBsum4cn7
PubMed25645674
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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