Structure of PDB 4a8p Chain E

Receptor sequence
>4a8pE (length=333) Species: 1351 (Enterococcus faecalis) [Search protein sequence]
MKRDYVTTETYTKEEMHYLVDLSLKIKEAIKNGYYPQLLKNKSLGMIFQQ
SSTRTRVSFETAMEQLGGHGEYLAPGQIHETIEDTSRVLSRLVDILMARV
ERHHSIVDLANCATIPVINGMSDYNHPTQELGDLCTMVEHLPEGKKLEDC
KVVFVGDATQVCFSLGLITTKMGMNFVHFGPEGFQLNEEHQAKLAKNCEV
SGGSFLVTDDASSVEGADFLYTDVWYGLYEAELSEEERMKVFYPKYQVNQ
EMMDRAGANCKFMHCLPATRGEEVTDEVIDGKNSICFDEAENRLTSIRGL
LVYLMNDYEAKNPYDLIKQAEAKKELEVFLDTQ
3D structure
PDB4a8p New Insight Into the Transcarbamylase Family: The Structure of Putrescine Transcarbamylase, a Key Catalyst for Fermentative Utilization of Agmatine
ChainE
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R54 T55 R103 H130 Q133 D227 C269 R297
Catalytic site (residue number reindexed from 1) R54 T55 R99 H126 Q129 D223 C265 R293
Enzyme Commision number 2.1.3.6: putrescine carbamoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PAO E S52 T53 R54 T55 R103 M125 H130 Q164 D227 L270 R297 S52 T53 R54 T55 R99 M121 H126 Q160 D223 L266 R293
Gene Ontology
Molecular Function
GO:0004585 ornithine carbamoyltransferase activity
GO:0016597 amino acid binding
GO:0016740 transferase activity
GO:0016743 carboxyl- or carbamoyltransferase activity
GO:0050231 putrescine carbamoyltransferase activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0006596 polyamine biosynthetic process
GO:0019240 citrulline biosynthetic process
GO:0033388 putrescine biosynthetic process from arginine
GO:0033390 putrescine biosynthetic process from arginine via N-carbamoylputrescine
GO:0042450 arginine biosynthetic process via ornithine
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4a8p, PDBe:4a8p, PDBj:4a8p
PDBsum4a8p
PubMed22363663
UniProtQ837U7|PTC_ENTFA Putrescine carbamoyltransferase (Gene Name=ptcA)

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