Structure of PDB 3wcd Chain E

Receptor sequence
>3wcdE (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
LSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDD
MTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNL
AEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSR
LFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEV
WSRYVKKLGDFALPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSV
FNFCAIPQVMAIATLAACYNNQQVFKGAVLIRLGQAVTLMMDATNMPAVK
AIIYQYMEEIYHRIPDSNPSSSKTRQIISTIRTQ
3D structure
PDB3wcd Squalene synthase as a target for Chagas disease therapeutics.
ChainE
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y171 R218 R228 F288
Catalytic site (residue number reindexed from 1) Y136 R183 R193 F253
Enzyme Commision number 2.5.1.21: squalene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RWY E Y73 R77 A176 V179 G180 L183 M207 G208 F288 C289 P292 Q293 Y38 R42 A141 V144 G145 L148 M172 G173 F253 C254 P257 Q258
Gene Ontology
Molecular Function
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0051996 squalene synthase [NAD(P)H] activity
Biological Process
GO:0008610 lipid biosynthetic process
GO:0009058 biosynthetic process
GO:0045338 farnesyl diphosphate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3wcd, PDBe:3wcd, PDBj:3wcd
PDBsum3wcd
PubMed24789335
UniProtP37268|FDFT_HUMAN Squalene synthase (Gene Name=FDFT1)

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