Structure of PDB 3w9j Chain E

Receptor sequence
>3w9jE (length=1030) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
MSKFFIDRPIFAWVIALVIMLAGGLSILSLPVNQYPAIAPPAIAVQVSYP
GASAETVQDTVVQVIEQQMNGIDNLRYISSESNSDGSMTITVTFEQGTDP
DIAQVQVQNKLQLATPLLPQEVQRQGIRVTKAVKNFLMVVGVVSTDGSMT
KEDLSNYIVSNIQDPLSRTKGVGDFQVFGSQYSMRIWLDPAKLNSYQLTP
GDVSSAIQAQNVQISSGQLGGLPAVKGQQLNATIIGKTRLQTAEQFENIL
LKVNPDGSQVRLKDVADVGLGGQDYSINAQFNGSPASGIAIKLATGANAL
DTAKAIRQTIANLEPFMPQGMKVVYPYDTTPVVSASIHEVVKTLGEAILL
VFLVMYLFLQNFRATLIPTIAVPVVLLGTFGVLAAFGFSINTLTMFGMVL
AIGLLVDDAIVVVENVERVMAEEGLSPREAARKSMGQIQGALVGIAMVLS
AVFLPMAFFGGSTGVIYRQFSITIVSAMALSVIVALILTPALCATMLKPI
EKGDHGEHKGGFFGWFNRMFLSTTHGYERGVASILKHRAPYLLIYVVIVA
GMIWMFTRIPTAFLPDEDQGVLFAQVQTPPGSSAERTQVVVDSMREYLLE
KESSSVSSVFTVTGFNFAGRGQSSGMAFIMLKPWEERPGGENSVFELAKR
AQMHFFSFKDAMVFAFAPPSVLELGNATGFDLFLQDQAGVGHEVLLQARN
KFLMLAAQNPALQRVRPNGMSDEPQYKLEIDDEKASALGVSLADINSTVS
IAWGSSYVNDFIDRGRVKRVYLQGRPDARMNPDDLSKWYVRNDKGEMVPF
NAFATGKWEYGSPKLERYNGVPAMEILGEPAPGLSSGDAMAAVEEIVKQL
PKGVGYSWTGLSYEERLSGSQAPALYALSLLVVFLCLAALYESWSIPFSV
MLVVPLGVIGALLATSMRGLSNDVFFQVGLLTTIGLSAKNAILIVEFAKE
LHEQGKGIVEAAIEACRMRLRPIVMTSLAFILGVVPLAISTGAGSGSQHA
IGTGVIGGMVTATVLAIFWVPLFYVAVSTL
3D structure
PDB3w9j Structural basis for the inhibition of bacterial multidrug exporters
ChainE
Resolution3.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P9D E R128 V139 Q176 V177 F178 G179 I277 Y327 F573 F610 V612 F615 F628 M630 R128 V139 Q176 V177 F178 G179 I277 Y327 F573 F610 V612 F615 F628 M630
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015562 efflux transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
GO:0042908 xenobiotic transport
GO:0046677 response to antibiotic
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:3w9j, PDBe:3w9j, PDBj:3w9j
PDBsum3w9j
PubMed23812586
UniProtP52002|MEXB_PSEAE Multidrug resistance protein MexB (Gene Name=mexB)

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