Structure of PDB 3w2c Chain E

Receptor sequence
>3w2cE (length=202) Species: 9606 (Homo sapiens) [Search protein sequence]
WALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQEVEIQSHLR
HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITE
LANALSYCKPENLLLGSAGELKIADTLDYLPPEMIEVDLWSLGVLCYEFL
VGKPPFEANTYQYKRISRVEFTFPDFVTEGARDLISRLLKHNPHPWITAN
SS
3D structure
PDB3w2c Flexibility and multiple conformations of the activation and glycine rich loops of aurora A accompanying inhibitor binding
ChainE
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N261 D274
Catalytic site (residue number reindexed from 1) N112 D125
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N15 E F144 K162 Q185 L194 L208 L210 A213 G216 L263 F17 K35 Q46 L55 L69 L71 A74 G77 L114
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007052 mitotic spindle organization
GO:0007098 centrosome cycle
GO:0007100 mitotic centrosome separation
GO:0051321 meiotic cell cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:3w2c, PDBe:3w2c, PDBj:3w2c
PDBsum3w2c
PubMed
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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