Structure of PDB 3w11 Chain E

Receptor sequence
>3w11E (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKL
IMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL
GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNEE
CGDICNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSEC
LGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDL
HHKQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPK
3D structure
PDB3w11 How insulin engages its primary binding site on the insulin receptor
ChainE
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E F39 K40 F35 K36
BS02 peptide E R14 L36 F64 F88 F89 Y91 F96 R118 R10 L32 F60 F84 F85 Y87 F92 R114
External links
PDB RCSB:3w11, PDBe:3w11, PDBj:3w11
PDBsum3w11
PubMed23302862
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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