Structure of PDB 3vra Chain E

Receptor sequence

>3vraE (length=613) Species: 6253 (Ascaris suum) [Search protein sequence]

AQYKVIDHAYDVVIIGAGGAGLRAAMGLGEAGFKTAVVTKMFPTRSHTTA
AQGGINAALGSMNPDDWKWHFYDTAKGSDWLGDQNAMHYLTRNAVEAVTE
LENFGMPFSRTPEGKIYQRSFGGQSNNYGKGGVAKRTCCVADRTGHSMLH
TLYGNSLRCHCTFFIEYFALDLLMDKGRCVGVIALCLEDGTIHRFRSKRT
IVATGGYGRAYFSCTTAHMNTGDGTALATRAGIALEDLEFIQFHPTGIYG
VGCLITEGSRGEGGFLVNSEGERFMERYAPKAKDLASRDVVSRAETIEIM
EGRGVGPEKDHIYLQLHHLPAEQLHQRLPGISETAKIFAGVDVTKEPIPV
IPTVHYNMGGIPTNYKAQVIKYTKEGGDKIVPGLYACGECACHSVHGANR
LGANSLLDAVVFGRACSINIKEELKPDEKIPELPEGAGEESIANLDAVRY
ANGDVPTAELRLTMQKTMQKHAGVFRRGDILAEGVKKMMDLSKELKRLKT
TDRSLIWNSDLTESLELQNLMLNATQTIVAAENRKESRGAHARDDFPKRE
DEYDYSKPIEGQTKRPFEKHWRKHTLTKQDPRTGHITLDYRPVIDKTLDP
AEVDWIPPIIRSY

3D structure

PDB

3vra Crystal structure of mitochondrial quinol-fumarate reductase from parasitic nematode Ascaris suum

Chain

Resolution

3.44 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	F153 Q274 H276 L286 E289 R292 R320 H387 Y388 R432
Catalytic site (residue number reindexed from 1)	F121 Q242 H244 L254 E257 R260 R288 H355 Y356 R400
Enzyme Commision number	1.3.5.1: succinate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	E	G48 A49 G50 G51 T71 K72 S78 H79 T80 A83 Q84 G85 G86 F200 A201 A235 T236 G237 D255 L286 H387 Y388 G420 E421 R432 A435 S437 L438	G16 A17 G18 G19 T39 K40 S46 H47 T48 A51 Q52 G53 G54 F168 A169 A203 T204 G205 D223 L254 H355 Y356 G388 E389 R400 A403 S405 L406

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0008177	succinate dehydrogenase (quinone) activity
GO:0009055	electron transfer activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

	Biological Process
GO:0006099	tricarboxylic acid cycle
GO:0006121	mitochondrial electron transport, succinate to ubiquinone
GO:0022900	electron transport chain

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0031966	mitochondrial membrane
GO:0045273	respiratory chain complex II (succinate dehydrogenase)

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:3vra, PDBe:3vra, PDBj:3vra
PDBsum	3vra
PubMed
UniProt	Q33862\|SDHA1_ASCSU Succinate dehydrogenase [rhodoquinone] flavoprotein subunit 1, mitochondrial (Gene Name=SDHA1)

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