Structure of PDB 3vc1 Chain E

Receptor sequence
>3vc1E (length=278) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence]
PAPATPYQEDIARYWNNEARPVNLRLGDVDGLYHHHYGIGPVDRAALGDP
EHSEYEKKVIAELHRLESAQAEFLMDHLGQAGPDDTLVDAGCGRGGSMVM
AHRRFGSRVEGVTLSAAQADFGNRRARELRIDDHVRSRVCNMLDTPFDKG
AVTASWNNESTMYVDLHDLFSEHSRFLKVGGRYVTITGCWNPRYGQPSKW
VSQINAHFECNIHSRREYLRAMADNRLVPHTIVDLTPDTLPYWELRATSS
LVTGIEKAFIESYRDGSFQYVLIAADRV
3D structure
PDB3vc1 Structure of Geranyl Diphosphate C-Methyltransferase from Streptomyces coelicolor and Implications for the Mechanism of Isoprenoid Modification.
ChainE
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.255: geranyl diphosphate 2-C-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH E Q22 W29 H49 H50 G105 G107 T127 L128 Q132 C154 N155 M156 N172 Y177 Q8 W15 H35 H36 G91 G93 T113 L114 Q118 C140 N141 M142 N158 Y163
BS02 GST E W29 V36 N37 H49 Y51 E173 M176 F222 R260 W15 V22 N23 H35 Y37 E159 M162 F208 R246
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008168 methyltransferase activity
GO:0008169 C-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:1904047 S-adenosyl-L-methionine binding
Biological Process
GO:0032259 methylation
GO:0042214 terpene metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3vc1, PDBe:3vc1, PDBj:3vc1
PDBsum3vc1
PubMed22455498
UniProtQ9F1Y5|GPPMT_STRCO Geranyl diphosphate 2-C-methyltransferase (Gene Name=SCO7701)

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