Structure of PDB 3uom Chain E

Receptor sequence

>3uomE (length=351) Species: 9606 (Homo sapiens) [Search protein sequence]

LDFPEYDGVDRVINVNAKNYKNVFKKYEVLALLYHEPPEDDKASQRQFEM
EELILELAAQVLEDKGVGFGLVDSEKDAAVAKKLGLTEVDSMYVFKGDEV
IEYDGEFSADTIVEFLLDVLEDPVELIEGERELQAFENIEDEIKLIGYFK
SKDSEHYKAFEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFME
EPVTIPDKPNSEEEIVNFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVA
FAEEADPDGFEFLETLKAVAQDNTENPDLSIIWIDPDDFPLLVPYWEKTF
DIDLSAPQIGVVNVTDADSVWMEMDDEEDLPSAEELEDWLEDVLEGEINT
E

3D structure

PDB

3uom High-capacity Ca2+ Binding of Human Skeletal Calsequestrin.

Chain

Resolution

2.02 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	E	D306 S308	D303 S305
BS02	CA	E	D259 D261	D256 D258
BS03	CA	E	D245 D247 I249	D242 D244 I246
BS04	CA	E	E102 V103	E99 V100
BS05	CA	E	D261 E264	D258 E261
BS06	CA	E	N17 V18 D80	N14 V15 D77
BS07	CA	E	D210 P212 E217	D207 P209 E214
BS08	CA	E	E199 T229	E196 T226
BS09	CA	E	E337 E340	E334 E337
BS10	CA	E	E337 D341	E334 D338
BS11	CA	E	E128 L129 E135	E125 L126 E132

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

	Biological Process
GO:0007029	endoplasmic reticulum organization
GO:0007519	skeletal muscle tissue development
GO:0009408	response to heat
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
GO:0014870	response to muscle inactivity
GO:0014894	response to denervation involved in regulation of muscle adaptation
GO:0045214	sarcomere organization
GO:0051258	protein polymerization
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051282	regulation of sequestering of calcium ion
GO:1901341	positive regulation of store-operated calcium channel activity
GO:2001256	regulation of store-operated calcium entry

	Cellular Component
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005783	endoplasmic reticulum
GO:0005790	smooth endoplasmic reticulum
GO:0014802	terminal cisterna
GO:0014804	terminal cisterna lumen
GO:0016020	membrane
GO:0016529	sarcoplasmic reticulum
GO:0030016	myofibril
GO:0030018	Z disc
GO:0030315	T-tubule
GO:0031674	I band
GO:0033017	sarcoplasmic reticulum membrane
GO:0033018	sarcoplasmic reticulum lumen
GO:0042383	sarcolemma

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:3uom, PDBe:3uom, PDBj:3uom
PDBsum	3uom
PubMed	22337878
UniProt	P31415\|CASQ1_HUMAN Calsequestrin-1 (Gene Name=CASQ1)

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