Structure of PDB 3siv Chain E

Receptor sequence
>3sivE (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
AAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESLVPNALDY
IRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLSEEELE
RLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVA
GGLTNLSKMPACNIMLLGAQVLPHTGYIYHSDIVQSLPPDLRRKAARLVA
AKCTLAARVDSFHESTEGKVGYELKDEIERKFDKWQ
3D structure
PDB3siv Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31.
ChainE
Resolution3.304 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna E M250 P269 H270 R289 R293 K298 K327 K330 M165 P173 H174 R193 R197 K202 K231 K234
BS02 rna E V234 M244 N248 L251 H270 V149 M159 N163 L166 H174
Gene Ontology
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000398 mRNA splicing, via spliceosome
Cellular Component
GO:0046540 U4/U6 x U5 tri-snRNP complex

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Biological Process
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Cellular Component
External links
PDB RCSB:3siv, PDBe:3siv, PDBj:3siv
PDBsum3siv
PubMed21784869
UniProtQ8WWY3|PRP31_HUMAN U4/U6 small nuclear ribonucleoprotein Prp31 (Gene Name=PRPF31)

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