Structure of PDB 3siu Chain E

Receptor sequence
>3siuE (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
AAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESLVPNALDY
IRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLSEEELE
RLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVA
GGLTNLSKMPACNIMLLGASVLPHTGYIYHSDIVQSLPPDLRRKAARLVA
AKCTLAARVDSFHESTEGKVGYELKDEIERKFDKWQ
3D structure
PDB3siu Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31.
ChainE
Resolution2.626 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna E C247 N248 M250 L251 L252 H270 R289 R293 A297 K298 K327 C162 N163 M165 L166 L167 H174 R193 R197 A201 K202 K231 PDBbind-CN: Kd=8uM
Gene Ontology
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000398 mRNA splicing, via spliceosome
Cellular Component
GO:0046540 U4/U6 x U5 tri-snRNP complex

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Biological Process
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Cellular Component
External links
PDB RCSB:3siu, PDBe:3siu, PDBj:3siu
PDBsum3siu
PubMed21784869
UniProtQ8WWY3|PRP31_HUMAN U4/U6 small nuclear ribonucleoprotein Prp31 (Gene Name=PRPF31)

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