Structure of PDB 3r5w Chain E

Receptor sequence
>3r5wE (length=109) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
KIPVALLTTTGRKTGQPRVNPLYFLRDGGRVIVAASKGGAEKNPMWYLNL
KANPKVQVQIKKEVLDLTARDATDEERAEYWPQLVTMYPSYQDYQSWTDR
TIPIVVCEP
3D structure
PDB3r5w Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824.
ChainE
Resolution1.786 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.-.-.-
1.1.98.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F42 E G53 R54 K55 T56 R60 N62 P63 L64 Y65 A76 S78 K79 P86 M87 W88 G11 R12 K13 T14 R18 N20 P21 L22 Y23 A34 S36 K37 P44 M45 W46 MOAD: Kd=1uM
BS02 F42 E P45 V46 K104 P3 V4 K62 MOAD: Kd=1uM
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:3r5w, PDBe:3r5w, PDBj:3r5w
PDBsum3r5w
PubMed22244759
UniProtP9WP15|DDN_MYCTU Deazaflavin-dependent nitroreductase (Gene Name=ddn)

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