Structure of PDB 3o8o Chain E

Receptor sequence
>3o8oE (length=752) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
QKKKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGG
KYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDA
LVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLV
GSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHC
GWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSKGRRNNTII
VAEGALDDQLNPVTANDVKDALIELGLDTKVTILGHVQRGGTAVAHDRWL
ATLQGVDAVKAVLEFTPETPSPLIGILENKIIRMPLVESVKLTKSVATAI
ENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVSDRLNIGIVHVG
APSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQTGEVKELSWIDVEN
WHNLGGSEIGTNRSVASEDLGTIAYYFQKNKLDGLIILGGFEGFRSLKQL
RDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQ
SASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIRED
ITLLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADIISEASKGKFGV
RTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEEDDSAAVIC
VNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGRLKLRAE
VA
3D structure
PDB3o8o The Crystal Structures of Eukaryotic Phosphofructokinases from Baker's Yeast and Rabbit Skeletal Muscle.
ChainE
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G215 R278 D309 S354 D356 D358 R400
Catalytic site (residue number reindexed from 1) G13 R76 D107 S152 D154 D156 R198
Enzyme Commision number 2.7.1.11: 6-phosphofructokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F6P E D356 M398 R400 E455 H488 R491 D154 M196 R198 E253 H286 R289
BS02 FDP E R665 S724 Q767 G769 E827 H859 R952 R463 S522 Q565 G567 E625 H657 R724
BS03 F6P E R391 K482 R189 K280
Gene Ontology
Molecular Function
GO:0003872 6-phosphofructokinase activity
GO:0005524 ATP binding
Biological Process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006096 glycolytic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3o8o, PDBe:3o8o, PDBj:3o8o
PDBsum3o8o
PubMed21241708
UniProtP16861|PFKA1_YEAST ATP-dependent 6-phosphofructokinase subunit alpha (Gene Name=PFK1)

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