Structure of PDB 3mlp Chain E

Receptor sequence

>3mlpE (length=303) Species: 10090 (Mus musculus) [Search protein sequence]

VLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIE
RTAFVGFVEKEKEANSEKTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMT
KQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDR
FFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVH
NNSKHGRRARRLDPSEAATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQ
VIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRF
IYT

3D structure

PDB

3mlp Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with Rel proteins

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	E	R63 N66 F67 H157 C161 S162 R163 N172 A202 G203 N204 R206 S238 K239 R245	R28 N31 F32 H122 C126 S127 R128 N137 A167 G168 N169 R171 S203 K204 R210
BS02	dna	E	G171 N174 N197 N201 A202 G203 N204 H235 N236 N237 H240	G136 N139 N162 N166 A167 G168 N169 H200 N201 N202 H205
BS03	ZN	E	H157 C161 C164 C170	H122 C126 C129 C135

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

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Biological Process

External links

PDB	RCSB:3mlp, PDBe:3mlp, PDBj:3mlp
PDBsum	3mlp
PubMed	20876732
UniProt	Q07802\|COE1_MOUSE Transcription factor COE1 (Gene Name=Ebf1)

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