Structure of PDB 3m7w Chain E

Receptor sequence
>3m7wE (length=251) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2) [Search protein sequence]
KTVTVRDLVVGEGAPKIIVSLMGKTITDVKSEALAYREADFDILEWRVDH
FANVTTAESVLEAAGAIREIITDKPLLFTFRSAKEGGEQALTTGQYIDLN
RAAVDSGLVDMIDLELFTGDDEVKATVGYAHQHNVAVIMSNHDFHKTPAA
EEIVQRLRKMQELGADIPKIAVMPQTKADVLTLLTATVEMQERYADRPII
TMSMSKTGVISRLAGEVFGSAATFGAVKKASAPGQISVADLRTVLTILHQ
A
3D structure
PDB3m7w Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates.
ChainE
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E86 H143 K170
Catalytic site (residue number reindexed from 1) E85 H142 K169
Enzyme Commision number 4.2.1.10: 3-dehydroquinate dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DQA E E46 R48 R82 H143 K170 R213 F225 S232 A233 Q236 E45 R47 R81 H142 K169 R212 F224 S231 A232 Q235
Gene Ontology
Molecular Function
GO:0003855 3-dehydroquinate dehydratase activity
GO:0016829 lyase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0046279 3,4-dihydroxybenzoate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3m7w, PDBe:3m7w, PDBj:3m7w
PDBsum3m7w
PubMed21087925
UniProtP58687|AROD_SALTY 3-dehydroquinate dehydratase (Gene Name=aroD)

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