Structure of PDB 3lsf Chain E

Receptor sequence
>3lsfE (length=258) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKLKNK
WWYDKGEC
3D structure
PDB3lsf Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors.
ChainE
Resolution1.851 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PZI E D248 N252 D245 N249
BS02 GLU E Y61 L90 T91 R96 G141 S142 T143 E193 Y58 L87 T88 R93 G138 S139 T140 E190
BS03 PZI E D216 S217 D213 S214
BS04 PZI E F106 M107 S242 L247 D248 F103 M104 S239 L244 D245
BS05 ZN E E42 H46 E39 H43
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:3lsf, PDBe:3lsf, PDBj:3lsf
PDBsum3lsf
PubMed20163115
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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