Structure of PDB 3k49 Chain E

Receptor sequence

>3k49E (length=353) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

SPLLEQLRNSSSNMSLKDIFGHSLEFCKDQHGSRFIQRELATSPASEKEV
IFNEIRDDAIELSNDVFGNYVIQKFFEFGSKIQKNTLVDQFKGNMKQLSL
QMYACRVIQKALEYIDSNQRIELVLELSDSVLQMIKDQNGNHVIQKAIET
IPIEKLPFILSSLTGHIYHLSTHSYGCRVIQRLLEFGSSEDQESILNELK
DFIPYLIQDQYGNYVIQYVLQQDQFTNKEMVDIKQEIIETVANNVVEYSK
HKFASNVVEKSILYGSKNQKDLIISKILPRDKNHALNLEDDSPMILMIKD
QFANYVIQKLVNVSEGEGKKLIVIAIRAYLDKLNKSNGNRHLASVEKLAA
LVE

3D structure

PDB

3k49 A 5' cytosine binding pocket in Puf3p specifies regulation of mitochondrial mRNAs.

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	E	Q550 R554 Q557 F587 N589 Y590 Q593 Y623 R626 Q629 Q658 N661 H662 Q665 C697 R698 Q701 N733 Y734 Q737 K772 S775 N776 E779 N824 Y825 L864 A865 S866 K869	Q30 R34 Q37 F67 N69 Y70 Q73 Y103 R106 Q109 Q138 N141 H142 Q145 C177 R178 Q181 N213 Y214 Q217 K252 S255 N256 E259 N304 Y305 L342 A343 S344 K347	PDBbind-CN: Kd=0.31nM

Gene Ontology

	Molecular Function
GO:0003723	RNA binding

View graph for
Molecular Function

External links

PDB	RCSB:3k49, PDBe:3k49, PDBj:3k49
PDBsum	3k49
PubMed	19918084
UniProt	Q07807\|PUF3_YEAST mRNA-binding protein PUF3 (Gene Name=PUF3)

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