Structure of PDB 3ik6 Chain E

Receptor sequence
>3ik6E (length=258) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKLKNK
WWYDKGEC
3D structure
PDB3ik6 Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
ChainE
Resolution2.101 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HCZ E I92 S108 S217 K218 G219 I89 S105 S214 K215 G216
BS02 HCZ E K104 P105 M107 S108 L239 K101 P102 M104 S105 L236
BS03 GLU E Y61 L90 T91 R96 G141 S142 T143 E193 Y58 L87 T88 R93 G138 S139 T140 E190
BS04 ZN E E42 H46 E39 H43
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:3ik6, PDBe:3ik6, PDBj:3ik6
PDBsum3ik6
PubMed19673491
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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