Structure of PDB 3hu2 Chain E

Receptor sequence
>3hu2E (length=452) Species: 9606 (Homo sapiens) [Search protein sequence]
LSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKG
KKRREAVCIVLSDDTCSDEKIRMNAVVRNNLRVRLGDVISIQPCPDVKYG
KRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAV
EFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRK
QLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANE
TGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAP
KREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFG
RFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADL
AALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNP
SA
3D structure
PDB3hu2 A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants.
ChainE
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.6: vesicle-fusing ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS E R359 F360 R348 F349
BS02 AGS E I206 G207 P247 G248 T249 G250 K251 T252 L253 N348 I380 H384 G408 A409 I195 G196 P236 G237 T238 G239 K240 T241 L242 N337 I369 H373 G397 A398
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:3hu2, PDBe:3hu2, PDBj:3hu2
PDBsum3hu2
PubMed20512113
UniProtP55072|TERA_HUMAN Transitional endoplasmic reticulum ATPase (Gene Name=VCP)

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