Structure of PDB 3h89 Chain E

Receptor sequence
>3h89E (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSE
QNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGI
YFEPDCSSEDMDHGVLVVGYGFESNKYWLVKNSWGEEWGMGGYVKMAKDR
RNHCGIASAASYPTV
3D structure
PDB3h89 A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors
ChainE
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H163 N187
Catalytic site (residue number reindexed from 1) Q19 C25 H163 N182
Enzyme Commision number 3.4.22.15: cathepsin L.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NSX E Q19 C25 G61 E63 G67 G68 L69 M70 A135 A138 G139 H140 E141 L144 D162 H163 W189 A214 Q19 C25 G61 E63 G67 G68 L69 M70 A135 A138 G139 H140 E141 L144 D162 H163 W184 A209 MOAD: Ki=0.023uM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3h89, PDBe:3h89, PDBj:3h89
PDBsum3h89
PubMed19761244
UniProtP07711|CATL1_HUMAN Procathepsin L (Gene Name=CTSL)

[Back to BioLiP]