Structure of PDB 3gft Chain E

Receptor sequence
>3gftE (length=163) Species: 9606 (Homo sapiens) [Search protein sequence]
FQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVID
GETCLLDILDTAGRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVK
DSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDD
AFYTLVREIRKHK
3D structure
PDB3gft Human K-Ras in complex with a GTP analogue
ChainE
Resolution2.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG E S17 T35 S20 T38
BS02 GNP E G13 G15 K16 S17 A18 F28 V29 D30 Y32 T35 G60 N116 K117 D119 L120 S145 A146 G16 G18 K19 S20 A21 F31 V32 D33 Y35 T38 G63 N112 K113 D115 L116 S141 A142
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:3gft, PDBe:3gft, PDBj:3gft
PDBsum3gft
PubMed
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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