Structure of PDB 3etd Chain E

Receptor sequence

>3etdE (length=501) Species: 9913 (Bos taurus) [Search protein sequence]

ADREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRETEEQKRNRVRGILR
IIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVS
VDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTM
ELAKKGFIGPGVDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTG
KPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFAVQ
GFGNVGLHSMRYLHRFGAKCVAVGESDGSIWNPDGIDPKELEDFKLQHGT
ILGFPKAKIYEGSILEVDCDILIPAASEKQLTKSNAPRVKAKIIAEGANG
PTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFK
YERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVH
SGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFRVYNEAGVTF
T

3D structure

PDB

3etd Novel Inhibitors Complexed with Glutamate Dehydrogenase: ALLOSTERIC REGULATION BY CONTROL OF PROTEIN DYNAMICS

Chain

Resolution

2.5 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	K126 D168
Catalytic site (residue number reindexed from 1)	K126 D168
Enzyme Commision number	1.4.1.3: glutamate dehydrogenase [NAD(P)(+)].

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	B1T	E	R146 R147	R146 R147	MOAD: ic50=4.8uM
BS02	GLU	E	K90 G92 K126 A166 P167 D168 N349 V378	K90 G92 K126 A166 P167 D168 N349 V378
BS03	NDP	E	D168 M169 R211 T215 Q250 F252 G253 V255 E275 S276 A326 G347 A348 N349 N374	D168 M169 R211 T215 Q250 F252 G253 V255 E275 S276 A326 G347 A348 N349 N374
BS04	GTP	E	R261 R265 E292 K446	R261 R265 E292 K446

Gene Ontology

	Molecular Function
GO:0004352	glutamate dehydrogenase (NAD+) activity
GO:0004353	glutamate dehydrogenase [NAD(P)+] activity
GO:0004354	glutamate dehydrogenase (NADP+) activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016491	oxidoreductase activity
GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
GO:0042802	identical protein binding

	Biological Process
GO:0006520	amino acid metabolic process
GO:0006538	glutamate catabolic process
GO:0006541	glutamine metabolic process
GO:0072350	tricarboxylic acid metabolic process

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005783	endoplasmic reticulum

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Molecular Function

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Cellular Component

External links

PDB	RCSB:3etd, PDBe:3etd, PDBj:3etd
PDBsum	3etd
PubMed	19531491
UniProt	P00366\|DHE3_BOVIN Glutamate dehydrogenase 1, mitochondrial (Gene Name=GLUD1)

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