Structure of PDB 3ccr Chain E

Receptor sequence
>3ccrE (length=172) Species: 2238 (Haloarcula marismortui) [Search protein sequence]
PRVELEIPEDVDAEQDHLDITVEGDNGSVTRRLWYPDIDVSVDGDTVVIE
SDEDNAKTMSTIGTFQSHIENMFHGVTEGWEYGMEVFYSHFPMQVNVEGD
EVVIENFLGEKAPRRTTIHGDTDVEIDGEELTVSGPDIEAVGQTAADIEQ
LTRINDKDVRVFQDGVYITRKP
3D structure
PDB3ccr Mutations outside the anisomycin-binding site can make ribosomes drug-resistant.
ChainE
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna E Y35 N55 A56 K57 S60 G63 T64 S67 H68 N71 Y82 H90 F91 G109 E110 K111 A112 H119 I138 E139 Q143 A146 R153 K157 D158 R160 V161 F162 Y35 N55 A56 K57 S60 G63 T64 S67 H68 N71 Y82 H90 F91 G109 E110 K111 A112 H119 I138 E139 Q143 A146 R153 K157 D158 R160 V161 F162 PDBbind-CN: Kd=100uM
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ccr, PDBe:3ccr, PDBj:3ccr
PDBsum3ccr
PubMed18455733
UniProtP14135|RL6_HALMA Large ribosomal subunit protein uL6 (Gene Name=rpl6)

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