Structure of PDB 3blv Chain E

Receptor sequence
>3blvE (length=344) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
ATAAQAERTLPKKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWE
TINIKEGVYEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYA
NVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMT
RPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKE
YPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPG
LVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLN
EYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM
3D structure
PDB3blv Allosteric Motions in Structures of Yeast NAD+-specific Isocitrate Dehydrogenase.
ChainE
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F136 K183 D217 T241 N245
Catalytic site (residue number reindexed from 1) F131 K178 D212 T236 N240
Enzyme Commision number 1.1.1.41: isocitrate dehydrogenase (NAD(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FLC E T83 S92 R98 R129 F136 T241 R274 T78 S87 R93 R124 F131 T236 R269
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004449 isocitrate dehydrogenase (NAD+) activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0006537 glutamate biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0042645 mitochondrial nucleoid
GO:0045242 isocitrate dehydrogenase complex (NAD+)

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Molecular Function
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Cellular Component
External links
PDB RCSB:3blv, PDBe:3blv, PDBj:3blv
PDBsum3blv
PubMed18256028
UniProtP28834|IDH1_YEAST Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial (Gene Name=IDH1)

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