Structure of PDB 2yhm Chain E

Receptor sequence
>2yhmE (length=375) Species: 11250 (human respiratory syncytial virus) [Search protein sequence]
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGM
LLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTH
RQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYR
HDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGL
LPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNA
YGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGF
YHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAA
KAYAEQLKENGVINYSVLDLTAEEL
3D structure
PDB2yhm Structures of Respiratory Syncytial Virus Nucleocapsid Protein from Two Crystal Forms: Details of Potential Packing Interactions in the Native Helical Form.
ChainE
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna E K170 A172 R184 R185 V189 I242 G254 V256 S313 T315 G335 E336 Y337 R338 K170 A172 R184 R185 V189 I242 G254 V256 S313 T315 G335 E336 Y337 R338
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030291 protein serine/threonine kinase inhibitor activity
Biological Process
GO:0019049 virus-mediated perturbation of host defense response
GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway
GO:0039545 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
GO:0039554 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
GO:0039580 symbiont-mediated suppression of host PKR/eIFalpha signaling
GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade
Cellular Component
GO:0019013 viral nucleocapsid
GO:0019028 viral capsid
GO:0019029 helical viral capsid
GO:0030430 host cell cytoplasm
GO:1990904 ribonucleoprotein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:2yhm, PDBe:2yhm, PDBj:2yhm
PDBsum2yhm
PubMed22102022
UniProtP03418|NCAP_HRSVA Nucleoprotein (Gene Name=N)

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